An orangutan from a San Diego Zoo has made medical history. Karen received a COVID-19 experimental vaccine designed for animals, making her one of the first great apes to do so. This is the second time Karen has made history. In 1994, she was the first orangutan in the world to receive open-heart surgery. The vaccine was developed by the veterinary pharmaceutical company Zoetis but is not suitable for humans. Around the world, it has been confirmed that various animals have been infected with COVID-19, including tigers, lions, minks, snow leopards, cougars, ferrets, dogs, and domestic cats; however, this information cannot be verified. There is still limited information on how the virus affects animals.